A Randomized Controlled Trial of Cold-Adapted and Inactivated Vaccines for the Prevention of Influenza A Disease
Identifieur interne : 001E13 ( Main/Exploration ); précédent : 001E12; suivant : 001E14A Randomized Controlled Trial of Cold-Adapted and Inactivated Vaccines for the Prevention of Influenza A Disease
Auteurs : Kathryn M. Edwards [États-Unis] ; William D. Dupont [États-Unis] ; Mary K. Westrich [États-Unis] ; Walton D. Plummer [États-Unis] ; Pamela S. Palmer [États-Unis] ; Peter F. Wright [États-Unis]Source :
- Journal of Infectious Diseases [ 0022-1899 ] ; 1994.
Abstract
A double-blind, randomized controlled trial over 5 years compared the safety, immunogenicity, and efficacy of cold-adapted and inactivated influenza A vaccines in 5210 normal subjects. Both vaccines were well tolerated. Inactivated vaccine significantly increased hemagglutination inhibition antibody titers. Significant titer rises were also noted after cold-adapted vaccine but of lesser magnitude than with inactivated vaccine. The efficacyof inactivated vaccine in preventing culture-positive influenza was 76% (95% confidence interval [CI], 58%–87%) for HINI disease and 74% (95% CI, 52%–86%) for H3N2; for cold-adapted vaccine, 85% (95% CI, 70%–92%) and 58% (95% CI, 29%–75%), respectively. The efficacy of inactivated vaccine in preventing a four-fold rise in antibody titer over the influenza season was 69% (95% CI, 61%–76%) for H1N1 and 73% (95% CI, 65%–79%) for H3N2; for cold-adapted vaccine, 54% (95% CI, 44%–62%) and 32% (95% CI, 17%–44%), respectively. Cold-adapted and inactivated influenza vaccines are safe and effective for preventing influenza A disease.
Url:
DOI: 10.1093/infdis/169.1.68
Affiliations:
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Edwards</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Division of Pediatric Infectious Diseases, Department of Pediatrics, and Division of Biostatistics, Department of Preventive Medicine, Vanderbilt University School of Medicine, Nashville</wicri:cityArea></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Reprints or correspondence: Dr. Kathryn M. Edwards, Division of Pediatric Infectious Diseases, Dept. of Pediatrics, D-7226 Medical Center N., Vanderbilt University School of Medicine, Nashville</wicri:cityArea></affiliation></author><author><name sortKey="Dupont, William D" sort="Dupont, William D" uniqKey="Dupont W" first="William D." last="Dupont">William D. Dupont</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Division of Pediatric Infectious Diseases, Department of Pediatrics, and Division of Biostatistics, Department of Preventive Medicine, Vanderbilt University School of Medicine, Nashville</wicri:cityArea></affiliation></author><author><name sortKey="Westrich, Mary K" sort="Westrich, Mary K" uniqKey="Westrich M" first="Mary K." last="Westrich">Mary K. Westrich</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Division of Pediatric Infectious Diseases, Department of Pediatrics, and Division of Biostatistics, Department of Preventive Medicine, Vanderbilt University School of Medicine, Nashville</wicri:cityArea></affiliation></author><author><name sortKey="Plummer, Walton D" sort="Plummer, Walton D" uniqKey="Plummer W" first="Walton D." last="Plummer">Walton D. Plummer</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Division of Pediatric Infectious Diseases, Department of Pediatrics, and Division of Biostatistics, Department of Preventive Medicine, Vanderbilt University School of Medicine, Nashville</wicri:cityArea></affiliation></author><author><name sortKey="Palmer, Pamela S" sort="Palmer, Pamela S" uniqKey="Palmer P" first="Pamela S." last="Palmer">Pamela S. Palmer</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Division of Pediatric Infectious Diseases, Department of Pediatrics, and Division of Biostatistics, Department of Preventive Medicine, Vanderbilt University School of Medicine, Nashville</wicri:cityArea></affiliation></author><author><name sortKey="Wright, Peter F" sort="Wright, Peter F" uniqKey="Wright P" first="Peter F." last="Wright">Peter F. Wright</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Division of Pediatric Infectious Diseases, Department of Pediatrics, and Division of Biostatistics, Department of Preventive Medicine, Vanderbilt University School of Medicine, Nashville</wicri:cityArea></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of Infectious Diseases</title><title level="j" type="abbrev">J Infect Dis.</title><idno type="ISSN">0022-1899</idno><idno type="eISSN">1537-6613</idno><imprint><publisher>The University of Chicago Press</publisher><date when="1994-01">1994</date><biblScope unit="vol">169</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="68">68</biblScope><biblScope unit="page" to="76">76</biblScope></imprint><idno type="ISSN">0022-1899</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-1899</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">A double-blind, randomized controlled trial over 5 years compared the safety, immunogenicity, and efficacy of cold-adapted and inactivated influenza A vaccines in 5210 normal subjects. Both vaccines were well tolerated. Inactivated vaccine significantly increased hemagglutination inhibition antibody titers. Significant titer rises were also noted after cold-adapted vaccine but of lesser magnitude than with inactivated vaccine. The efficacyof inactivated vaccine in preventing culture-positive influenza was 76% (95% confidence interval [CI], 58%–87%) for HINI disease and 74% (95% CI, 52%–86%) for H3N2; for cold-adapted vaccine, 85% (95% CI, 70%–92%) and 58% (95% CI, 29%–75%), respectively. The efficacy of inactivated vaccine in preventing a four-fold rise in antibody titer over the influenza season was 69% (95% CI, 61%–76%) for H1N1 and 73% (95% CI, 65%–79%) for H3N2; for cold-adapted vaccine, 54% (95% CI, 44%–62%) and 32% (95% CI, 17%–44%), respectively. Cold-adapted and inactivated influenza vaccines are safe and effective for preventing influenza A disease.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Tennessee</li></region></list><tree><country name="États-Unis"><region name="Tennessee"><name sortKey="Edwards, Kathryn M" sort="Edwards, Kathryn M" uniqKey="Edwards K" first="Kathryn M." last="Edwards">Kathryn M. Edwards</name></region><name sortKey="Dupont, William D" sort="Dupont, William D" uniqKey="Dupont W" first="William D." last="Dupont">William D. Dupont</name><name sortKey="Edwards, Kathryn M" sort="Edwards, Kathryn M" uniqKey="Edwards K" first="Kathryn M." last="Edwards">Kathryn M. Edwards</name><name sortKey="Palmer, Pamela S" sort="Palmer, Pamela S" uniqKey="Palmer P" first="Pamela S." last="Palmer">Pamela S. Palmer</name><name sortKey="Plummer, Walton D" sort="Plummer, Walton D" uniqKey="Plummer W" first="Walton D." last="Plummer">Walton D. Plummer</name><name sortKey="Westrich, Mary K" sort="Westrich, Mary K" uniqKey="Westrich M" first="Mary K." last="Westrich">Mary K. Westrich</name><name sortKey="Wright, Peter F" sort="Wright, Peter F" uniqKey="Wright P" first="Peter F." last="Wright">Peter F. Wright</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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